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Abstract #3039

A Trimodal non-Gaussian Diffusion Model for the Full Spectrum of Multi-b Diffusion MRI in Brain Tissue

Nicholas W. Damen1,2, Kejia Cai2,3,4, Yi Sui2,4, Muge Karaman2, and Frederick C. Damen2,3

1Illinois Math and Science Academy, Aurora, IL, United States, 2Center for Magnetic Resonance Research, University of Illinois at Chicago, Chicago, IL, United States, 3Radiology, University of Illinois Medical Center, Chicago, IL, United States, 4Bioengineering, University of Illinois at Chicago, Chicago, IL, United States

When examining brain diffusion weighted MRI (DW-MRI) images acquired at multiple diffusion weightings, i.e., b-values, it has become apparent that the DW-MRI measurements may not be completely explained with a Gaussian mono-exponential model. A trimodal model is proposed to fit the full spectrum of multi-b DW-MRI (from 0 to 5000 s/mm2) by incorporating a perfusion component, a stretch exponential component, and a 3rd distinct diffusion component. The trimodal model reduced the χ2 fitting residuals, provided an additional 3rd diffusion component with good white matter contrast without sacrificing contrast in the perfusion and stretch exponential components.

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