Abstract #3039

A Trimodal non-Gaussian Diffusion Model for the Full Spectrum of Multi-b Diffusion MRI in Brain Tissue

Nicholas W. Damen^1,2, Kejia Cai^2,3,4, Yi Sui^2,4, Muge Karaman², and Frederick C. Damen^2,3

¹Illinois Math and Science Academy, Aurora, IL, United States, ²Center for Magnetic Resonance Research, University of Illinois at Chicago, Chicago, IL, United States, ³Radiology, University of Illinois Medical Center, Chicago, IL, United States, ⁴Bioengineering, University of Illinois at Chicago, Chicago, IL, United States

When examining brain diffusion weighted MRI (DW-MRI) images acquired at multiple diffusion weightings, i.e., b-values, it has become apparent that the DW-MRI measurements may not be completely explained with a Gaussian mono-exponential model. A trimodal model is proposed to fit the full spectrum of multi-b DW-MRI (from 0 to 5000 s/mm²) by incorporating a perfusion component, a stretch exponential component, and a 3^rd distinct diffusion component. The trimodal model reduced the χ² fitting residuals, provided an additional 3^rd diffusion component with good white matter contrast without sacrificing contrast in the perfusion and stretch exponential components.

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