Abstract #3045

Angular Complexity and Fractional Displacement Probability: New metrics for diffusion propagator imaging

Luis Miguel Lacerda¹, Gareth Barker¹, and Flavio Dell'Acqua¹

¹Department of Neuroimaging, The Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom

Several methods have been used to represent the diffusion signal, and recently novel multi-shell approaches like SHORE, have allowed analytical and continuous reconstruction of the diffusion propagator. In this study, we propose two new metrics to better characterize the propagator at different displacement radii, the Angular Complexity Index (ACI), as a measure of propagator anisotropy, and the Fractional Displacement Probability (FDP), as index of relative mean displacement probability within fixed displacement bands. Furthermore, we display preliminary results that suggest sensitivity to microstructural organisation at different displacement scales, as opposed to traditional propagator metrics that reduce it to single scalar maps.

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