Szabolcs David1, Anneriet Heemskerk1, Max Viergever1, and Alexander Leemans1
motion during diffusion weighted MRI acquisition is a well-known confounding
factor which can affect diffusion tensor metrics. In this simulation study, we investigated
whether this confound is related to the change in distribution of diffusion
gradient orientations due to the required “B-matrix rotation” during subject
motion. According to our findings, subject motion can indeed generate a
significant angular bias in addition to the noise bias, suggesting that subject
motion itself may cause group differences in diffusion metrics.