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Abstract #3051

The effect of subject motion on fractional anisotropy estimates: A simulation study of angular bias

Szabolcs David1, Anneriet Heemskerk1, Max Viergever1, and Alexander Leemans1

1Image Sciences Institute, UMC Utrecht, Utrecht, Netherlands

Subject motion during diffusion weighted MRI acquisition is a well-known confounding factor which can affect diffusion tensor metrics. In this simulation study, we investigated whether this confound is related to the change in distribution of diffusion gradient orientations due to the required “B-matrix rotation” during subject motion. According to our findings, subject motion can indeed generate a significant angular bias in addition to the noise bias, suggesting that subject motion itself may cause group differences in diffusion metrics.

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