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Abstract #3066

A comparison of multiple acquisition strategies to overcome B1 inhomogeneities in diffusion imaging of post-mortem human brain at 7T

Sean Foxley1, Saad Jbabdi1, Moises Hernandez Fernandez1, Connor Scott2, Olaf Ansorge2, and Karla Miller1

1FMRIB Centre, University of Oxford, Oxford, United Kingdom, 2Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

In this work we compare a single flip angle and dual flip angle approach to overcome B1 inhomogeneities in DW-SSFP data of post mortem human brain at 7T. Both approaches were designed and optimized to achieve optimal CNR with whole brain coverage. The single flip angle approach displayed slight improvements in orientation estimates; however, the dual flip angle approach is being further investigated as a potential source of microstructural estimates with little to no cost in orientation.

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