Abstract #3069

A New Method to Construct and Validate an Optic Radiation Template using Probabilistic Tractography

Chenyu Wang^1,2, Alexander Klistorner^1,3,4, Linda Ly^1,2, Ruth A Oliver^1,2, and Michael H Barnett^1,2

¹Sydney Neuroimaging Analysis Centre, Camperdown, Sydney, Australia, ²Brain and Mind Centre, University of Sydney, Camperdown, Sydney, Australia, ³Ophthalmology, Save Sight Institute, University of Sydney, Sydney, Australia, ⁴Australian School of Advanced Medicine, Macquarie University, Sydney, Australia

In-vivo delineation the white matter (WM) fibre bundles with diffusion-weighted imaging (DWI) and tractography facilitates the study of tract-specific damage due to neurological disease. However, this approach is limited by suboptimal or absent DWI datasets. Accurate atlas based white matter segmentation may provide an alternative method that can be broadly applied to existing neuroimaging datasets . Using the optic radiation as an example, we propose a new framework for the mapping and validation of white matter tracts in healthy subjects using probabilistic tractography.

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