Abstract #3078

Longitudinal Comparison of Diffusion Imaging Modeling in Rat Spinal Cord Injury

Nathan P Skinner^1,2,3, Sean D McGarry⁴, Shekar N Kurpad^3,5, Brian D Schmit⁶, and Matthew D Budde^3,5

¹Biophysics Graduate Program, Medical College of Wisconsin, Milwaukee, WI, United States, ²Medical Scientist Training Program, Medical College of Wisconsin, Milwaukee, WI, United States, ³Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States, ⁴Neuroscience Doctoral Program, Medical College of Wisconsin, Milwaukee, WI, United States, ⁵Clement J. Zablocki Veteran's Affairs Medical Center, Milwaukee, WI, United States, ⁶Department of Biomedical Engineering, Marquette University, Milwaukee, WI, United States

A rat model of graded spinal cord injury was used to evaluate several diffusion models for the ability to detect injury at acute and chronic time points. Parameters from diffusion tensor imaging, free water estimation, diffusion kurtosis imaging, and white matter tract integrity models demonstrated that higher order modeling showed better separation of injury severity, especially in the chronic time point. Furthermore, parameters sensitive to volume changes associated with edema and inflammation demonstrated the greatest separation of these injury groups, indicating the importance of these processes in altering diffusion characteristics in spinal cord injury.

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