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Abstract #3086

Diffusion microstructure in the population: variability and effect size of biophysical compartment model parameters over 100 subjects

Robbert Harms1, Rainer Goebel1, and Alard Roebroeck1

1Maastricht University, Maastricht, Netherlands

Statistical power in neuroscience studies is often limited, leading to, among others, low reproducibility of results[1]. Robust effect size estimates over a large subject group are crucial for power assessments. Here, we computed these estimates for microstructural differences in splenium, body and genu of the Corpus Callosum (CC) using diffusion MRI microstructure modeling over 100 subjects. We fitted Tensor, Ball&Stick, NODDI and CHARMED using GPU-accelerated software (MDT) and extracted subject specific parameters for the CC for each model. We observe medium to large effect sizes (Cohen’s d=1-3) for dMRI microstructure measures, promising for power and reproducibility of dMRI microstructure studies.

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