Abstract #3086

Diffusion microstructure in the population: variability and effect size of biophysical compartment model parameters over 100 subjects

Robbert Harms¹, Rainer Goebel¹, and Alard Roebroeck¹

¹Maastricht University, Maastricht, Netherlands

Statistical power in neuroscience studies is often limited, leading to, among others, low reproducibility of results[1]. Robust effect size estimates over a large subject group are crucial for power assessments. Here, we computed these estimates for microstructural differences in splenium, body and genu of the Corpus Callosum (CC) using diffusion MRI microstructure modeling over 100 subjects. We fitted Tensor, Ball&Stick, NODDI and CHARMED using GPU-accelerated software (MDT) and extracted subject specific parameters for the CC for each model. We observe medium to large effect sizes (Cohen’s d=1-3) for dMRI microstructure measures, promising for power and reproducibility of dMRI microstructure studies.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.