Statistical
power in neuroscience studies is often limited, leading to, among
others, low reproducibility of results[1]. Robust effect size
estimates over a large subject group are crucial for power
assessments. Here, we computed these estimates for microstructural
differences in splenium, body and genu of the Corpus Callosum (CC)
using diffusion MRI microstructure modeling over 100 subjects. We
fitted Tensor, Ball&Stick, NODDI and CHARMED using
GPU-accelerated software (MDT) and extracted subject specific
parameters for the CC for each model. We observe medium to large
effect sizes (Cohen’s d=1-3) for dMRI microstructure measures,
promising for power and reproducibility of dMRI microstructure
studies.
