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Abstract #3088

Precise Inference of Cellular and Axonal Structural Organization (PICASO) using diffusion MRI

Lipeng Ning1,2, Carl-Fredrik Westin1,2, and Yogesh Rathi1,2

1Brigham and Women's Hospital, Boston, MA, United States, 2Harvard Medical School, Boston, MA, United States

We propose a novel model termed PICASO for investigating the microstructural layout of brain tissue using in vivo diffusion MRI (dMRI) measurements. Our method provides a direct connection between the structural organization of biological tissue and a function representing the disorder in the evolution of magnetization density. This is achieved by extending the Bloch-Torrey equation to include variability in diffusivity due to restrictions and hindrances. Using in vivo data from the Humman Connectome Project (HCP), we show that the PICASO model can provide novel information about the microstructural layout of the axonal packing in human brain. Thus, our method can be applied in clinical settings to investigate brain abnormalities.

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