Cytoarchitectonic abnormalities along white matter pathways in temporal lobe epilepsy: Combining diffusional kurtosis imaging and automated fiber quantification
Russell Glenn1, Jens H Jensen1, Simon S Keller2, Joseph A Helpern1, and Leonardo Bonilha3
1Medical University of South Carolina, Charleston, SC, United States, 2University of Liverpool, Liverpool, United Kingdom, 3Charleston, SC, United States
lobe epilepsy (TLE) is the most common form of medically refractory epilepsy
and is associated with focal brain abnormalities causing recurrent, unprovoked
seizures originating from the temporal lobe. However, cytoarchitectronic
changes can be detected outside of the temporal lobe and may be associated with
the clinical course of the disease. We implement a novel neuroimaging approach
which combines the strengths of diffusional kurtosis imaging and automated
fiber quantification for the non-invasive characterization of white matter
pathways and demonstrate its sensitivity to detect pathological alterations
associated with TLE. The proposed technique may provide further insights into
the clinicopathology of TLE.
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