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Abstract #3093

Cytoarchitectonic abnormalities along white matter pathways in temporal lobe epilepsy: Combining diffusional kurtosis imaging and automated fiber quantification

Russell Glenn1, Jens H Jensen1, Simon S Keller2, Joseph A Helpern1, and Leonardo Bonilha3

1Medical University of South Carolina, Charleston, SC, United States, 2University of Liverpool, Liverpool, United Kingdom, 3Charleston, SC, United States

Temporal lobe epilepsy (TLE) is the most common form of medically refractory epilepsy and is associated with focal brain abnormalities causing recurrent, unprovoked seizures originating from the temporal lobe. However, cytoarchitectronic changes can be detected outside of the temporal lobe and may be associated with the clinical course of the disease. We implement a novel neuroimaging approach which combines the strengths of diffusional kurtosis imaging and automated fiber quantification for the non-invasive characterization of white matter pathways and demonstrate its sensitivity to detect pathological alterations associated with TLE. The proposed technique may provide further insights into the clinicopathology of TLE.

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