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Abstract #3106

CMR Assessment of an Isoproterenol Infusion Mouse Model of Myocardial Hypertrophy and Fibrosis

Haiying Tang1, Matthew Fronheiser1, Harold Malone1, Paul Sleph2, Adrienne Pena1, Thomas Petrone1, Thomas Bradstreet1, Patrick Chow1, Lei Zhao2, David Gordon2, Feng Luo3, and Wendy Hayes1

1Bristol Myers Squibb, Princeton, NJ, United States, 2Bristol Myers Squibb, Hopewell, NJ, United States, 3Bristol Myers Squibb, Wallingford, CT, United States

Recent advances in cardiovascular MRI (CMR) technologies such as T1-mapping or extracellular volume (ECV) fraction (derived from T1-mapping) offer robust techniques to assess diffuse fibrosis in patients with myocardial infarction and heart failure. In the present study, CMR assessment of myocardial fibrosis and hypertrophy was evaluated in an isoproterenol infusion model in Balb/c mice. The CMR techniques including T1-mapping and the ECV quantification provide a translational non-invasive imaging marker to assess diffuse myocardial fibrosis, and the potential to evaluate efficacy of anti-fibrosis treatment.

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