Abstract #3106

CMR Assessment of an Isoproterenol Infusion Mouse Model of Myocardial Hypertrophy and Fibrosis

Haiying Tang¹, Matthew Fronheiser¹, Harold Malone¹, Paul Sleph², Adrienne Pena¹, Thomas Petrone¹, Thomas Bradstreet¹, Patrick Chow¹, Lei Zhao², David Gordon², Feng Luo³, and Wendy Hayes¹

¹Bristol Myers Squibb, Princeton, NJ, United States, ²Bristol Myers Squibb, Hopewell, NJ, United States, ³Bristol Myers Squibb, Wallingford, CT, United States

Recent advances in cardiovascular MRI (CMR) technologies such as T1-mapping or extracellular volume (ECV) fraction (derived from T1-mapping) offer robust techniques to assess diffuse fibrosis in patients with myocardial infarction and heart failure. In the present study, CMR assessment of myocardial fibrosis and hypertrophy was evaluated in an isoproterenol infusion model in Balb/c mice. The CMR techniques including T1-mapping and the ECV quantification provide a translational non-invasive imaging marker to assess diffuse myocardial fibrosis, and the potential to evaluate efficacy of anti-fibrosis treatment.

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