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Abstract #3115

A comparison of M012 compensated spin-echo and STEAM cardiac DTI at multiple cardiac phases

Andrew David Scott1,2, Sonia Nielles-Vallespin1,3, Pedro Ferreira1,2, Peter Gatehouse1,2, Zohya Khalique1, Philip Kilner1,2, Dudley Pennell1,2, and David Firmin1,2

1Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield Foundation NHS Trust, London, United Kingdom, 2National Heart and Lung Institute, Imperial College London, London, United Kingdom, 3National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States

In-vivo cardiac diffusion tensor imaging (cDTI) performed with a stimulated echo (STEAM) sequence is considered strain sensitive and low SNR. Alternatively, motion compensated spin-echo (M012-SE) sequences are thought to be strain insensitive and high SNR, but suffer from long echo times and short mixing times. In this work we compare the reliability of and the cDTI parameters derived from STEAM and M012-SE data in 20 volunteers at mutliple points in the cardiac cycle on a standard clinical scanner. We show systematic differences between the sequences and show that there are few correlations between these differences and strain and/or T1/T2.

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