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Abstract #3130

Quantitative, Time-efficient, Heart-Rate Independent Myocardial BOLD MRI with Whole-heart Coverage at 3T in a Canine Model of Coronary Stenosis with Simultaneous 13N-Ammonia PET Validation

Hsin-Jung Yang1, Damini Dey1, Jane Sykes2, John Butler2, Xiaoming Bi3, Behzad Sharif1, Sotirios Tsaftaris4, Debiao Li1, Piotr Slomka1, Frank Prato2, and Rohan Dharmakumar1

1Cedars Sinai Medical Center, Los Angeles, CA, United States, 2Lawson Health Research Institute, london, ON, Canada, 3Siemens Healthcare, Los Angeles, CA, United States, 4IMT Institute for Advanced Studies Lucca, Lucca, Italy

Current myocardial BOLD MR methods are limited by: (a) poor spatial coverage and imaging speed; (b) imaging confounders; and (c) imaging artifacts, particularly at 3T. To address these limitations, we developed a heart-rate independent, free-breathing 3D T2 mapping technique at 3T that utilizes near 100% imaging efficiency, which can be completed in 3 minutes with full LV coverage. We tested our method in a canine model of coronary stenosis and validated our findings with simultaneously acquired13N-ammonia PET perfusion data in a whole-body PET/MR system.

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