Abstract #3141

A Computational Fluid Dynamics Simulation Study on the Influence of the Tortuosity of the Coronary Arteries on Contrast Agent Bolus Dispersion in Contrast-Enhanced Myocardial Perfusion MRI

Regine Schmidt¹, Hanns-Christian Breit¹, and Laura Maria Schreiber^1,2

¹Section of Medical Physics, Department of Radiology, Johannes Gutenberg University Medical Center, Mainz, Germany, ²Department of Cellular and Molecular Imaging, Comprehensive Heart Failure Center (CHFC), Wuerzburg, Germany

The dispersion of the contrast agent bolus at T1-weighted contrast-enhanced first-pass myocardial perfusion MRI was examined by means of computational fluid dynamics simulations. In this study simulations in idealized coronary artery geometries with different extent of vessel tortuosity and in a straight reference vessel geometry have been performed for the condition of rest and stress. The contrast agent bolus dispersion was larger at rest compared to stress. Furthermore, a negative correlation between the extent of tortuosity and the contrast agent bolus dispersion was found.

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