Abstract #3145

Double-gated Myocardial ASL Perfusion Imaging provides Insensitivity to Heart Rate Variation

Hung Phi Do¹, Andrew J Yoon², Michael W Fong², Farhood Saremi³, Mark L Barr⁴, and Krishna S Nayak⁵

¹Department of Physics and Astronomy, University of Southern California, Los Angeles, CA, United States, ²Department of Medicine, Divison of Cardiology, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States, ³Department of Radiology, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States, ⁴Department of Cardiothoracic Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States, ⁵Ming Hsieh Department of Electrical Engineering, University of Southern California, Los Angeles, CA, United States

Double-gating in myocardial ASL allows for variations in the post-labeling delay in order to ensure that both labeling and imaging occur in the same cardiac phase. Originally proposed by Poncelet et al. in 1999, this was believed to provide insensitivity to heart rate variation. Despite this, most groups have utilized single-gating with a fixed post-labeling delay for pairs of control and tagged images, since this allows for simpler quantification of myocardial blood flow. In this study, we demonstrate that the double-gating is indeed more robust to heart rate variation compared to single-gating for myocardial ASL, based on experiments in healthy volunteers and heart transplant recipients.

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