Abstract #3164

Rapid T1-Mapping of Mouse Hearts using Real-Time MRI

Tobias Wech¹, Nicole Seiberlich², Andreas Schindele³, Alfio Borzì³, Herbert Köstler¹, and Jürgen E. Schneider⁴

¹Department of Diagnostical and Interventional Radiology, University of Würzburg, Würzburg, Germany, ²Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ³Institute of Mathematics, University of Würzburg, Würzburg, Germany, ⁴Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom

The feasibility of using real-time MRI to determine $$$T_1$$$ relaxation times in mouse hearts was explored. An inversion recovery prepared and highly undersampled radial acquisition was applied and data were reconstructed using a combination of through-time radial GRAPPA and compressed sensing. The ECG in combination with the DC-signal recorded for each projection was used to eliminate cardiac and respiratory motion, which allowed for fitting $$$T_1$$$-values in every voxel. The method was applied to five mice in vivo and the measured $$$T_1$$$-values found for myocardial tissue agreed well with literature. Our work indicates that it is possible to accurately measure $$$T_1$$$ in mice using real-time MRI.

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