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Abstract #3164

Rapid T1-Mapping of Mouse Hearts using Real-Time MRI

Tobias Wech1, Nicole Seiberlich2, Andreas Schindele3, Alfio Borzì3, Herbert Köstler1, and Jürgen E. Schneider4

1Department of Diagnostical and Interventional Radiology, University of Würzburg, Würzburg, Germany, 2Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 3Institute of Mathematics, University of Würzburg, Würzburg, Germany, 4Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom

The feasibility of using real-time MRI to determine $$$T_1$$$ relaxation times in mouse hearts was explored. An inversion recovery prepared and highly undersampled radial acquisition was applied and data were reconstructed using a combination of through-time radial GRAPPA and compressed sensing. The ECG in combination with the DC-signal recorded for each projection was used to eliminate cardiac and respiratory motion, which allowed for fitting $$$T_1$$$-values in every voxel. The method was applied to five mice in vivo and the measured $$$T_1$$$-values found for myocardial tissue agreed well with literature. Our work indicates that it is possible to accurately measure $$$T_1$$$ in mice using real-time MRI.

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