Abstract #3178

Spectrally selective 3D dynamic bSSFP for hyperpolarized C-13 metabolic imaging at 14.1T

Hong Shang^1,2, Subramaniam Sukumar¹, Robert A. Bok¹, Irene Marco-Rius¹, Cornelius von Morze¹, Adam B. Kerr³, Galen Reed⁴, Michael Ohliger¹, John Kurhanewicz¹, Peder E. Z. Larson¹, John M. Pauly³, and Daniel B. Vigneron¹

¹Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, ²Bioengineering, UC Berkeley - UCSF, San Francisco / Berkeley, CA, United States, ³Electrical Engineering, Stanford University, Stanford, CA, United States, ⁴HeartVista, Menlo Park, CA, United States

Balanced SSFP sequences can provide superior SNR efficiency for hyperpolarized ¹³C imaging, by efficiently utilizing the non-recoverable magnetization. A spectrally selective bSSFP sequence was developed to enable fast mapping of hyperpolarized metabolites. A novel approach for bSSFP spectral selectivity was developed utilizing a combination of optimized multiband RF pulses and a bSSFP pulse train with a carefully chosen TR to avoid banding artifact. The sequence enabled 3D dynamic imaging of HP resonances generated in studies with co-polarized pyruvate and urea (with ~1% selectivity), attaining 2mm isotropic resolution and <1s temporal resolution.

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