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Abstract #3210

Ultrafast volumetric cine MRI (VC-MRI) for real-time 3D target localization in radiation therapy

Wendy Harris1,2, Fang-Fang Yin1,2, Chunhao Wang1,2, Zheng Chang1,2, Jing Cai1,2, You Zhang1,2, and Lei Ren1,2

1Department of Radiation Oncology, Duke University, Durham, NC, United States, 2Medical Physics Graduate Program, Duke University, Durham, NC, United States

A novel technique has been developed to generate ultra-fast high-quality volumetric cine MRI (VC-MRI) using patient prior information. The VC-MRI was generated by deforming the prior volumetric MRI images based on ultra-fast on-board 2D-cine MRI and patient PCA-based respiratory breathing model. The ultra-fast 2D-cine images were acquired by sampling about 10% of k-space. The undersampled cine images were reconstructed using an iterative MR reconstruction algorithm with a total generalized variation penalty. The technique was evaluated using both anthropomorphic digital phantom and patient data. Results demonstrated the feasibility of generating ultrafast-VC-MRI for both inter-and intra-fraction verification of moving targets in radiotherapy.

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