Abstract #3210

Ultrafast volumetric cine MRI (VC-MRI) for real-time 3D target localization in radiation therapy

Wendy Harris^1,2, Fang-Fang Yin^1,2, Chunhao Wang^1,2, Zheng Chang^1,2, Jing Cai^1,2, You Zhang^1,2, and Lei Ren^1,2

¹Department of Radiation Oncology, Duke University, Durham, NC, United States, ²Medical Physics Graduate Program, Duke University, Durham, NC, United States

A novel technique has been developed to generate ultra-fast high-quality volumetric cine MRI (VC-MRI) using patient prior information. The VC-MRI was generated by deforming the prior volumetric MRI images based on ultra-fast on-board 2D-cine MRI and patient PCA-based respiratory breathing model. The ultra-fast 2D-cine images were acquired by sampling about 10% of k-space. The undersampled cine images were reconstructed using an iterative MR reconstruction algorithm with a total generalized variation penalty. The technique was evaluated using both anthropomorphic digital phantom and patient data. Results demonstrated the feasibility of generating ultrafast-VC-MRI for both inter-and intra-fraction verification of moving targets in radiotherapy.

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