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Abstract #3267

Comparison of Gradient Echo MRI Water-Fat separation and single voxel 1H MRS for liver fat fraction measurements in a dietary intervention study at 3T

Stephen Bawden1,2, Carolyn Chee3, Caroline Hoad1, Guruprasad Aithal2, Ian Macdonald3, Richard Bowtell1, and Penny Gowland1

1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2NIHR Nottingham Digestive Diseases Research Unit, University of Nottingham, Nottingham, United Kingdom, 3School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

This study compared hepatic fat fraction measured using MRS and gradient echo MRI at 3T. Fitting algorithms using a single fat peak and multiple fat peaks were compared with MRS data at TE=20ms and also T2-corrected MRS. Individual differences between T2 values of water and fat calculated from MRS were also used to estimate the difference between R2*-water and R2*-fat and included in the multi peak fitting per subject. The results showed a good correlation between multi-peak and MRS data (R2 = 0.9), but applying T2-correction to MRS increased the scatter (R2 = 0.67) and systematic error (gradient = 1.34). Using the new R2* corrected fitting algorithm resulted in similar scatter (R2 = 0.66) but improved systematic error (gradient = 1.09). The results from this study indicate the dual-R2* fitting is important at 3T and further developments should be made to optimize these methods.

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