Abstract #3305

A standardised clinical multicentric whole brain T2* mapping protocol at 3T

David Gay¹, Marie Chupin^1,2, Jean-François Mangin^1,3, Cyril Poupon^1,4, Hugo Dary¹, Takoua Kaaouana², Paulo Loureiro de Sousa⁵, Christine Delmaire⁶, Ludovic De Rochefort⁷, Jean-Marie Bonny⁸, and Alexandre Vignaud⁴

¹CATI Multicenter Neuroimaging Platform, cati-neuroimaging.com, Paris, France, ²ICM - Institut du Cerveau et de la Moelle Epinière, Paris, France, ³CEA, DSV, I2BM, NeuroSpin, UNATI, Gif-sur-Yvette, France, ⁴CEA, DSV, I2BM, NeuroSpin, UNIRS, Gif-sur-Yvette, France, ⁵Université de Strasbourg, CNRS, ICube, FTMS, Strasbourg, France, ⁶Neuroradiology, CHRU Roger Salengro, Lille, France, ⁷Université Paris-Sud, CNRS, IR4M UMR8081, Université Paris-Saclay, Orsay, France, ⁸INRA, UR370 QuaPA, Saint-Genès Champanelle, France

The purpose of this work is to report the implementation of a T2* map in multicenter neuroimaging studies. We focus on T2* because it is an endogenous biomarker for paramagnetic products like iron or melanin, which is very interesting to assess, among other diseases, Parkinson’s disease. We developed a MR sequence which meets several specific requirements. This sequence is accessible on 3 major manufacturer 3T MRI scanners and ensures good measurement accuracy at a standard millimeter isotropic resolution. This “universal” sequence allows to acquire, in a reliable and repeatable way, T2* maps of the whole brain.

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