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Abstract #3313

Automatic assessment of corpus callosum malformation from structural MRI images to improve diagnosis reproducibility.

Denis Peruzzo1, Umberto Castellani2, Fabio Triulzi1,3, Andrea Righini4, Cecilia Parazzini4, and Filippo Arrigoni1

1Neuroimaging Unit, Scientific Institute IRCCS “Eugenio Medea”, Bosisio Parini, Italy, 2Department of Computer Science, University of Verona, Verona, Italy, 3Department of Neuroradiolody, Fondazione IRCCS “Ca’ Granda” Ospedale Maggiore Policlinico, Milano, Italy, 4Department of Pediatric Radiology and Neuroradiology, Children Hospital “Vittorio Buzzi”, Milano, Italy

The diagnosis of brain malformations is usually based on the visual inspection of MRI images by trained neuroradiologists. The resulting procedure is therefore subjective and mainly provides a qualitative description of the detected malformations. In this study, we propose an assisted diagnosis tool (ADT) for the analysis of the corpus callosum from structural T1-weighted images. The method detects and characterizes different kind of malformations (local/diffuse, homogeneous/heterogeneous). Inter-subject reproducibility experiments showed that the agreement rate significantly improved from 67.5% to 79.3% using the proposed method.

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