Reduced Distortion Artifact Whole Brain CBF Mapping using Blip-Reversed Non-Segmented 3D Echo Planar Imaging
Neville D Gai1, Yi Yu Chou1,2, Dzung Pham1,2, and John A Butman1
1Radiology & Imaging Sciences, NIH, Bethesda, MD, United States, 2Center for Neuroscience and Regenerative Medicine, Henry Jackson Foundation, Bethesda, MD, United States
spin labeling is typically performed with segmented k-space acquisition schemes
to reduce B0 inhomogeneity related distortion. Non-segmented techniques offer the
advantage of higher SNR/time allowing greater
brain coverage in shorter scan times. Here we use a modified 3D EPI acquisition
scheme along with pseudo-continuous arterial spin labeling to correct for B0
inhomogeneity related distortion. By employing phase encoding along opposite
directions in alternating control-label pairs and with subsequent
post-processing, we correct for the distortion. CBF images were compared with
GM masks obtained from relatively distortion free MPRAGE images to show
improved localization of the CBF maps.
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