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Abstract #3322

Insula Cortex Parcellation with Q-ball Residual Bootstrap Tractography Algorithm

Maria Luisa Mandelli1, Matteo Paoletti2, Nico Papinutto3, Bagrat Amirbekian3,4, Roland G Henry3,4,5, Eduardo Caverzasi3,6, and Maria Luisa Gorno-Tempini1

1Neurology, Memory Aging Center, UCSF, San Francisco, CA, United States, 2Radiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, 3Neurology, UCSF, San Francisco, CA, United States, 4Bioengineering Graduate Group, Berkeley, CA, United States, 5Radiology and Biomedical Imaging, San Francisco, CA, United States, 6Brain and Behavioral Sciences, Pavia, Italy

The insula cortex is involved in different functions, however its cortical connections have not yet been extensively explored. Whole brain tractography with Q-ball residual bootstrap algorithm was performed in 17 controls. Insula and the cortex regions were used as ending-ROIs. We found structural connections between the insula and 22 cortical regions for each hemisphere. After registered the images to the MNI space, the parcellation of the insula was obtained based on the ending-tract connected with each of the cortex region. Availability of a template atlas of insular structural connectivity would contribute to a better understanding of its multiple functions.

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