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Abstract #3347

Quantification of the effect of head-down tilt posture on intracranial condition using MRI

Naoki Ohno1, Tosiaki Miyati1, Shinnosuke Hiratsuka2, Shota Ishida3, Noam Alperin4, Satoshi Kobayashi1, and Toshifumi Gabata5

1Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan, 2Department of Radiology, Shiga University of Medical Science Hospital, Otsu, Japan, 3Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan, 4Department of Radiology, University of Miami, Miami, FL, United States, 5Department of Radiology, Kanazawa University, Kanazawa, Japan

To quantify the effect of posture on intracranial condition, we assessed intracranial volume change (ΔICVC), pressure gradient (ΔPG), intracranial compliance index (ICCI), and apparent diffusion coefficient (ADC) change of the brain during the cardiac cycle (ΔADC) in head-down tilt (HDT) and horizontal supine positions. ΔPG was significantly increased on HDT compared with that in the horizontal supine position because of the intracranial pressure compensatory mechanism. However, there were no significant differences in other parameters between postures. ΔPG analysis in the HDT and horizontal supine positions makes it possible to evaluate intracranial conditions concerning the intracranial pressure compensatory faculty.

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