Abstract #3359

Finding biomarkers of cognitive decline in active professional fighters with multimodal MRI and exploring the longitudinal relationship of these biomarkers with cognitive decline

Virendra R Mishra¹, Xiaowei Zhuang¹, Karthik Sreenivasan¹, Zhengshi Yang¹, Sarah Banks¹, Charles Bernick¹, and Dietmar Cordes¹

¹Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States

Several cross-sectional MRI studies have shown structural differences in professional fighters but there has been no results reported in longitudinal studies of such active fighters. The professional fighters brain health study (PFBHS) is a longitudinal study of active professional fighters with age-matched healthy controls using multimodal MRI methods. In this study, we show that the features/biomarkers predicting cognitive decline at baseline are sensitive and specific over time in our cohort of longitudinal active fighters. Our study opens a new window to predict and monitor cognitive decline in patients with traumatic brain injuries.

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