Abstract #3361

Gray Matter Alterations Using Voxel-Based Morphometry May Not Reflect Changes In Morphometry: A Study of Mild Traumatic Brain Injury

Sohae Chung^1,2, Yadi Li³, Jacqueline Smith^1,2, Steven R Flanagan⁴, and Yvonne W Lui^1,2

¹Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, NY, United States, ²Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, United States, ³Department of Radiology, The Affiliated Ningbo Medical Treatment Center Lihuili Hospital of Ningbo University, Zhejiang, China, People's Republic of, ⁴Department of Rehabilitation Medicine, New York University Langone Medical Center, New York, NY, United States

Voxel-based morphometry (VBM) analysis has been used to detect morphometric changes of the GM after mild traumatic brain injury (mTBI). Spatially normalized and modulated GM density from VBM analysis is typically interpreted as GM volume. VBM is, however, sensitive not only to changes in volume but to variations in T1 relaxation. In this study, we investigated alterations in GM density using simulated images and VBM followed by an in vivo study of cortical GM morphometry using GM density and cortical thickness in mTBI patients and matched controls.

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