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Abstract #3393

Structural brain connectome and cognitive impairment in Parkinson’s disease

Sebastiano Galantucci1, Federica Agosta1, Elka Stefanova2, Silvia Basaia1, Martijn van den Heuvel3, Tanja Stojković2, Elisa Canu1, Iva Stanković2, Vladana Spica2, Vladimir S. Kostic2, and Massimo Filippi1,4

1Neuroimaging Research Unit, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, 2Clinic of Neurology, Faculty of Medicine, University of Belgrade, Belgrade, Yugoslavia, 3Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, Netherlands, 4Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

To date, MRI biomarkers have been demonstrated extremely useful for detecting and monitoring the neurodegenerative processes. However, brain network analysis seems the most powerful approach to quantitatively describe the topological organization of the brain connectome even at early stages of neurodegenerative diseases. This study provided promising biomarkers to detect features of neurodegeneration in PD-MCI, being able to distinguish it from PD without MCI. This study shows that the presence of subtle cognitive deficits not causing a dementia, produces a huge alteration of brain networks suggesting the importance of the study of connectomics in the investigation of neurodegenerative diseases.

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