Abstract #3393

Structural brain connectome and cognitive impairment in Parkinson’s disease

Sebastiano Galantucci¹, Federica Agosta¹, Elka Stefanova², Silvia Basaia¹, Martijn van den Heuvel³, Tanja Stojković², Elisa Canu¹, Iva Stanković², Vladana Spica², Vladimir S. Kostic², and Massimo Filippi^1,4

¹Neuroimaging Research Unit, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, ²Clinic of Neurology, Faculty of Medicine, University of Belgrade, Belgrade, Yugoslavia, ³Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

To date, MRI biomarkers have been demonstrated extremely useful for detecting and monitoring the neurodegenerative processes. However, brain network analysis seems the most powerful approach to quantitatively describe the topological organization of the brain connectome even at early stages of neurodegenerative diseases. This study provided promising biomarkers to detect features of neurodegeneration in PD-MCI, being able to distinguish it from PD without MCI. This study shows that the presence of subtle cognitive deficits not causing a dementia, produces a huge alteration of brain networks suggesting the importance of the study of connectomics in the investigation of neurodegenerative diseases.

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