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Abstract #3399

Brain Iron Deficiency in Restless Legs Syndrome Measured by Quantitative Susceptibility and its Relation to Clinical Features

Xu Li1,2, Hongjun Liu1,2, Richard P Allen3, Christopher J Earley3, Richard A.E. Edden1,2, Peter B Barker1,2, Tiana Cruz3, and Peter C.M. van Zijl1,2

1F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 2Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Possible brain iron deficiency was assessed using quantitative susceptibility mapping at 7T in restless legs syndrome (RLS) and analyzed with clinical measurements including IRLS severity score, serum iron, serum ferritin and periodic limb movement during sleep (PLMS). Using magnetic susceptibility as a brain iron index and compared to control group, significantly decreased iron was found in RLS patients in dentate nuclei and thalamus, and in substantia nigra in a subset of RLS patients with severe clinical symptoms with PLMS larger than 100 times per hour. Significant correlation between PLMS and brain iron was only found in substantia nigra in RLS.

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