Abstract #3408

Early aging effect on the function of human central olfactory system

Jianli Wang¹, Xiaoyu Sun¹, and Qing X Yang¹

¹Penn State College of Medicine, Hershey, PA, United States

We report an olfactory fMRI study of the aging effect on the functions of central olfactory system during normal adulthood and early aging. The smell identification function declined with age. Accordingly, the BOLD signal responding to odor stimulations was significantly decreased with age in bilateral DLPFC, left orbitofrontal cortex, and left insula. However, there was no significant age correlation was detected with the BOLD signal in the primary olfactory cortex. These results suggest that age-related olfactory functional decline in human brain is more prominent in the secondary and higher order central olfactory structures than the POC in early aging process.

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