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Abstract #3414

The Relationship between White Matter Structure and Clinical Behavior in Different APOE Genotypes: A Preliminary Study in Cognitively Intact Elderly.

Xiao Luo1, Yerfan Jiaerken1, and MinMing Zhang1

1Radiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China, People's Republic of

The purpose of this research was to study the relationship of white matter hyperintensities (WMH) with cognitive performance in healthy elderly with different APOE genotypes. In total, 158 subjects were separated into 3 groups (ε2 carriers, ε4 carriers and ε3 homozygotes). Group differences of regional WMH volume were calculated. Subsequent correlation analysis between regional WMH burden and behavior data was performed. Detrimental effect of APOE ε4 allele on white matter structure was found while no protective effect of APOE ε2 was observed; WMH volume was significantly correlated with processing speed and executive ability, especially in APOE ε4 carriers.

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