Abstract #3422

Age-related variability of functional connectivity in the basal ganglia in healthy elderly subjects and its implications for research in Parkinson’s disease

Ludovica Griffanti¹, Philipp Stratmann^2,3, Michal Rolinski², Nicola Filippini^1,2, Enikő Zsoldos², Abda Mahmood², Mika Kivimäki⁴, Archana Singh-Manoux⁴, Klaus P. Ebmeier², and Clare E. Mackay²

¹FMRIB centre, University of Oxford, Oxford, United Kingdom, ²Department of Psychiatry, University of Oxford, Oxford, United Kingdom, ³Department of Informatics, Technische Universität München, München, Germany, ⁴Department of Epidemiology and Public Health, University College London, London, United Kingdom

This exploratory study aims to identify factors that may account for variability in functional connectivity within the basal ganglia resting state network (BGN) in healthy subjects, to help the development of an imaging biomarker for Parkinson’s disease. To this purpose we explored the relationship between functional connectivity measures derived from resting state fMRI and several demographic, behavioral and motor variables, in a large population-based sample of healthy elderly subjects, participating in the Whitehall II imaging sub-study.

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