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Abstract #3422

Age-related variability of functional connectivity in the basal ganglia in healthy elderly subjects and its implications for research in Parkinson’s disease

Ludovica Griffanti1, Philipp Stratmann2,3, Michal Rolinski2, Nicola Filippini1,2, Enikő Zsoldos2, Abda Mahmood2, Mika Kivimäki4, Archana Singh-Manoux4, Klaus P. Ebmeier2, and Clare E. Mackay2

1FMRIB centre, University of Oxford, Oxford, United Kingdom, 2Department of Psychiatry, University of Oxford, Oxford, United Kingdom, 3Department of Informatics, Technische Universität München, München, Germany, 4Department of Epidemiology and Public Health, University College London, London, United Kingdom

This exploratory study aims to identify factors that may account for variability in functional connectivity within the basal ganglia resting state network (BGN) in healthy subjects, to help the development of an imaging biomarker for Parkinson’s disease. To this purpose we explored the relationship between functional connectivity measures derived from resting state fMRI and several demographic, behavioral and motor variables, in a large population-based sample of healthy elderly subjects, participating in the Whitehall II imaging sub-study.

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