Abstract #3458

Feasibility of vertebral bone Diffusion Weighted MR Imaging (DWI) for early diagnosis of hepatic osteodystrophy in Primary Sclerosing Cholangitis

Sarah Keller¹, Fabian Kording¹, Hendrick Kooijman², Christoph Schramm³, Roland Fischer⁴, Adam Gerhard¹, Ansgar Lohse³, Harald Ittrich¹, and Jin Yamamura¹

¹Diagnostic and Interventional Radiology, University Medical Center Hamburg Eppendorf (UKE), Hamburg, Germany, ²MRI, Philips GmbH, Hamburg, Germany, ³Department of Internal Medicine, University Medical Center Hamburg Eppendorf (UKE), Hamburg, Germany, ⁴Biochemistry, University Medical Center Hamburg Eppendorf (UKE), Hamburg, Germany

Hepatic osteodystrophy is a frequent complication in patients with chronic cholestatic and non-choleatatic liver disease, affecting up to 20-30% of patients [1, 2]. Besides conventional dual x-ray absorbtiometry (DXA) scans, diffusion-weighted MRI (DWI) has been performed for the evaluation of osteoporosis and osteopenia in risk patients. Follow up MRI examinations of PSC patients, to exclude malignancy and identify bile duct stenosis, are frequently performed in clinical routine. The aim of this study was to test the feasibility of add-on DWI sequences during routine examination for the detection of early changes of the bone marrow density (BMD) in comparison to DXA T-score values of the vertebral bone and healthy controls.

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