Meeting Banner
Abstract #3458

Feasibility of vertebral bone Diffusion Weighted MR Imaging (DWI) for early diagnosis of hepatic osteodystrophy in Primary Sclerosing Cholangitis

Sarah Keller1, Fabian Kording1, Hendrick Kooijman2, Christoph Schramm3, Roland Fischer4, Adam Gerhard1, Ansgar Lohse3, Harald Ittrich1, and Jin Yamamura1

1Diagnostic and Interventional Radiology, University Medical Center Hamburg Eppendorf (UKE), Hamburg, Germany, 2MRI, Philips GmbH, Hamburg, Germany, 3Department of Internal Medicine, University Medical Center Hamburg Eppendorf (UKE), Hamburg, Germany, 4Biochemistry, University Medical Center Hamburg Eppendorf (UKE), Hamburg, Germany

Hepatic osteodystrophy is a frequent complication in patients with chronic cholestatic and non-choleatatic liver disease, affecting up to 20-30% of patients [1, 2]. Besides conventional dual x-ray absorbtiometry (DXA) scans, diffusion-weighted MRI (DWI) has been performed for the evaluation of osteoporosis and osteopenia in risk patients. Follow up MRI examinations of PSC patients, to exclude malignancy and identify bile duct stenosis, are frequently performed in clinical routine. The aim of this study was to test the feasibility of add-on DWI sequences during routine examination for the detection of early changes of the bone marrow density (BMD) in comparison to DXA T-score values of the vertebral bone and healthy controls.

This abstract and the presentation materials are available to members only; a login is required.

Join Here