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Abstract #3469

Diffusion weighted imaging of prostate cancer: mathematical modeling of signal obtained using low b values

Harri Merisaari1, Parisa Movahedi1, Ileana Montoya1, Jussi Toivonen1, Marko Pesola1, Pekka Taimen2, Peter Boström2, Tapio Pahikkala1, Hannu Juhani Aronen1, and Ivan Jambor1

1University of Turku, Turku, Finland, 2Turku University Hospital, Turku, Finland

Eighty-one patients with historically confirmed PCa underwent two repeated 3T DWI examinations performed using 14 b-values in the range of 0-500 s/mm2 and diffusion time of 19.004 ms. Various fitting methods for IVIM and mathematical models were evaluated in the terms of fitting quality (Akaike information criteria), repeatability, and Gleason score prediction. Monoexponential model demonstrated the highest repeatability and clinical values in the regions-of-interest based analysis of PCa DWI, b-values in the range of 0-500 s/mm2.

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