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Abstract #3480

Quantitative Diffusion MRI of Hematopoietic Acute Radiation Syndrome using a Minipig Model

Frederick C. Damen1,2, Matthew Lindeblad3, Kejia Cai2,4, Michael Flannery2, Yi Sui2, Amelia M Bartholomew5, Aleksander V Lyubimov3, and Xiaohong Joe Zhou2,4,6,7

1Radiology, University of Illinois at Chicago, Chicago, IL, United States, 2Center for Magnetic Resonance Research, University of Illinois at Chicago, Chicago, IL, United States, 3Pharmacology, University of Illinois Medical Center, Chicago, IL, United States, 4Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, 5Surgery, University of Illinois Medical Center, Chicago, IL, United States, 6Radiology, Chicago, IL, United States, 7Neurosurgery, University of Illinois at Chicago, Chicago, IL, United States

The purpose of this study is to characterize Hematopoietic Acute Radiation Syndrome (hARS) and assess the effect of total body irradiation in a Göttingen minipig model using quantitative diffusion MRI. The minipigs were irradiated at a total dose of either 1.65 Gy (LD30/45 days) or 1.90 Gy (LD70/45 days). The animals underwent diffusion MRI scans prior to and again at 8, 15, or 22 days following irradiation. The consistent diffusion value prior to irradiation and the significant changes post-irradiation, both observed in this study, suggest that quantitative diffusion MR can be a viable marker for studying the effect of total body irradiation.

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