Abstract #3480

Quantitative Diffusion MRI of Hematopoietic Acute Radiation Syndrome using a Minipig Model

Frederick C. Damen^1,2, Matthew Lindeblad³, Kejia Cai^2,4, Michael Flannery², Yi Sui², Amelia M Bartholomew⁵, Aleksander V Lyubimov³, and Xiaohong Joe Zhou^2,4,6,7

¹Radiology, University of Illinois at Chicago, Chicago, IL, United States, ²Center for Magnetic Resonance Research, University of Illinois at Chicago, Chicago, IL, United States, ³Pharmacology, University of Illinois Medical Center, Chicago, IL, United States, ⁴Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, ⁵Surgery, University of Illinois Medical Center, Chicago, IL, United States, ⁶Radiology, Chicago, IL, United States, ⁷Neurosurgery, University of Illinois at Chicago, Chicago, IL, United States

The purpose of this study is to characterize Hematopoietic Acute Radiation Syndrome (hARS) and assess the effect of total body irradiation in a Göttingen minipig model using quantitative diffusion MRI. The minipigs were irradiated at a total dose of either 1.65 Gy (LD30/45 days) or 1.90 Gy (LD70/45 days). The animals underwent diffusion MRI scans prior to and again at 8, 15, or 22 days following irradiation. The consistent diffusion value prior to irradiation and the significant changes post-irradiation, both observed in this study, suggest that quantitative diffusion MR can be a viable marker for studying the effect of total body irradiation.

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