Abstract #3515

High Spatial Resolution Functional Imaging of Human Temporal Lobe Cortical Layers at 3T

Pu-Yeh Wu¹, Ying-Hua Chu¹, Shang-Yueh Tsai², Wen-Jui Kuo³, and Fa-Hsuan Lin¹

¹Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, ²Institute of Applied Physics, National Chengchi University, Taipei, Taiwan, ³Institute of Neuroscience, National Yang Ming University, Taipei, Taiwan

By using a dedicated 24-channel coil array and tailored sequence, we achieved human temporal lobe functional imaging with 1.5 mm isotropic resolution. Our coil array had two-fold SNR and tSNR improvement in the temporal lobe compared to a 32-channel whole-head coil array. Functional MRI showed more robust BOLD signals elicited by music stimuli in the primary auditory cortex. Tonotopic mapping revealed the clearest frequency progressions in the middle layer of auditory cortex gray matter, which was consistent with the result acquired by electrophysiological recordings on rodents.

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