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Abstract #3572

In-Bore MRI-Guided Transperineal Prostate Biopsy using 4-DOF Needle-Guide Manipulator

Junichi Tokuda1, Kemal Tuncali1, Gang Li2, Nirav Patel2, Tamas Heffter3, Gregory S Fischer2, Iulian I Iordachita4, Everette Clif Burdette 3, Nobuhiko Hata1, and Clare M Tempany1

1Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States, 2Department of Mechanical Engineering, Worcester Polytechnic Institute, Worcester, MA, United States, 3Acoustic MedSystems Inc., Savoy, IL, United States, 4Department Of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, United States

We present the clinical feasibility of our MRI-compatible 4-DOF needle-guide manipulator for in-bore MRI-guided transperineal prostate biopsy. Total 11 men were biopsied in a 3T MRI scanner using this manipulator. All 11 procedures were successfully performed in 102.6±24.5 minutes with targeting errors of 4.9±2.9 mm. The targeting errors were consistent with other clinical studies. Pathology results confirmed prostate cancer with Gleason score ≥ 6 in 5/6 men with previous negative TRUS biopsies, and upgraded 2/5 men on active surveillance to clinically significant cancer with Gleason score 7. In conclusion, In-bore MRI-guided prostate biopsy using the manipulator was feasible.

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