Abstract #3586

Hindered diffusion of Gadolinium-based Contrast Agents in rat brain extracellular micro-environment after ultrasound-induced delivery

Allegra Conti^1,2, Rémi Magnin^1,3, Matthieu Gerstenmayer¹, François Lux⁴, Olivier Tillement⁴, Sébastien Mériaux ¹, Stefania Della Penna², Gian Luca Romani², Erik Dumont³, Denis Le Bihan¹, and Benoît Larrat¹

¹CEA/DSV/I2BM/NeuroSpin, Gif Sur Yvette, France, ²Department of Neuroscience, Imaging and Clinical Sciences, G. D'Annunzio, University of Chieti and Pescara, Chieti, Italy, ³Image Guided Therapy, Pessac, France, ⁴Université Lyon 1, Lyon, France

We present here a new method to study the diffusion process of Gadolinium-based Contrast Agents within the brain extracellular space after the artificial Blood-Brain Barrier opening induced by ultrasound. Four compounds were tested (MultiHance, Gadovist, Dotarem and AGuIX). By estimating the Free Diffusion Coefficients from in vitro studies, and the Apparent Diffusion Coefficients from in vivo experiments, an evaluation of the tortuosity (λ) in the right striatum of 11 Sprague-Dawley rats has been performed. The values of λ are in agreement with literature and demonstrate that the chosen permeabilization protocol maintains the integrity of brain tissue.

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