Abstract #3650

Accurate and precise dynamic contrast enhanced (DCE) measurements with reduced gadolinium toxicity by lengthening pre-injection baseline

Samuel Barnes¹, Thomas Ng², and Russell Jacobs³

¹Radiology, Loma Linda University Medical Center, Loma Linda, CA, United States, ²Radiology, Brigham and Women's Hospital, Boston, MA, United States, ³Caltech, Pasadena, CA, United States

For increased patient safety it is desirable to acquire dynamic contrast enhanced (DCE) MRI data with the lowest passable Gd contrast agent (CA) dose. However, a lower CA dose generally leads to smaller signal changes and lower quality studies. Through simulations we show that lower CA doses (up to 1/2 dose) can be compensated for by extending the pre-injection baseline acquisition time to maintain similar accuracy and precision of the fitted K_trans values.

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