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Abstract #3695

Simultaneously Trace Blood Perfusion and Glymphatic Passage by Analyzing Deuterium Oxide Perfusion Imaging with a Two-Compartment Parallel Model

Cheng-He Li1, Zi-Min Lei1, Sheng-Min Huang1, Chin-Tien Lu1, Kung-Chu Ho2, and Fu-Nien Wang1

1Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2Nuclear Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan

This study tried to simultaneously trace blood perfusion and glymphatic passage by applying two-compartment parallel model (2CPM) on D2O perfusion using the new imaging strategy. Six rats were injected with D2O, and both F1 and F2 were quantified from 2CPM. The results show that F1 is highly coordinated with cerebral blood flow, while F2 is much irrelevant. Only regions near several arteries show significant F2 values, which is speculated as the paravascular pathway of CSF regulated by glymphatic system. Therefore, using 2CPM for tracing D2O might noninvasively reveal the information of both blood and CSF dynamics.

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