Abstract #3695

Simultaneously Trace Blood Perfusion and Glymphatic Passage by Analyzing Deuterium Oxide Perfusion Imaging with a Two-Compartment Parallel Model

Cheng-He Li¹, Zi-Min Lei¹, Sheng-Min Huang¹, Chin-Tien Lu¹, Kung-Chu Ho², and Fu-Nien Wang¹

¹Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, ²Nuclear Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan

This study tried to simultaneously trace blood perfusion and glymphatic passage by applying two-compartment parallel model (2CPM) on D₂O perfusion using the new imaging strategy. Six rats were injected with D₂O, and both F₁ and F₂ were quantified from 2CPM. The results show that F₁ is highly coordinated with cerebral blood flow, while F₂ is much irrelevant. Only regions near several arteries show significant F₂ values, which is speculated as the paravascular pathway of CSF regulated by glymphatic system. Therefore, using 2CPM for tracing D₂O might noninvasively reveal the information of both blood and CSF dynamics.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.