Abstract #3697

Development of intravascular SPION with tunable pharmacokinetics and relaxivity for preclinical fMRI and micro-MRA

Manasmita Das^1,2, Esteban Oyarzabal¹, Heather Decot¹, Xiopeng Zong¹, Neal Shah¹, Sung Ho Lee¹, Jonathan Edward Frank¹, Nazar A Filnov³, and Yen-Yu Ian Shih^1,2

¹Biomedical Research Imaging Center, UNC Chapel Hill, Chapel Hill, NC, United States, ²Department of Neurology, University of North Carolina Chapel Hill, Chapel Hill, NC, United States, ³SOP-CNDD, UNC Chapel Hill, Chapel Hill, NC, United States

We have developed a simple, inexpensive method to synthesize high-performance intravascular SPION in house. We were able to tune the relaxivity and PK profile of our home-made SPION via careful surface functionalization control and came up with an optimal formulation that offered very robust and stable contrast for high resolution cerebromicroangiography and steady state CBV functional imaging. Our future studies will focus on developing novel MR-detectable inflammation markers using our home-made iron oxide as the platform material.

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