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Abstract #3717

Comparison of Physiological Noise in Multiband-EPI and Regular EPI fMRI

Zahra Faraji-Dana1,2, Ali Golestani3, Yasha Khatamian3, Simon Graham1,2, and J. Jean Chen1,3

1Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Sunnybrook Research Institute, Sunnybrook Health Science Centre, Toronto, ON, Canada, 3Rotman Research Institute, Baycrest Health Science Centre, Toronto, ON, Canada

Simultaneous multi-slice echo-planer imaging (EPI) or otherwise known as multiband (MB) EPI provides high temporal and/or spatial resolution in resting-state fMRI (rs-fMRI) studies by modulating and simultaneously imaging multiple slices. However, the effect of slice acceleration on "physiological noise" induced by respiration, cardiac pulsation, variations in respiratory-volume (RVT) and cardiac-rate (CRV) is still unknown. Similar to conventional parallel imaging techniques, residual aliasing occur in MB slice acceleration that could introduce spurious signals into fMRI data. We hypothesize that since a given group of simultaneously acquired slices samples the physiological noise at the same time, the effect of physiological noise may be amplified in MB-EPI. In this study we experimentally verify this hypothesis, and identify the physiological-correction strategy that best corrects this effect.

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