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Abstract #3725

Echo-Time Optimization in Spin Echo EPI using Hypercapnic Manipulation at 3T

Don Marcial Ragot1,2 and Jean Chen1,2

1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Roman Research Institute, Toronto, ON, Canada

The optimal echo time (TE) for spin-echo EPI (SE-EPI) BOLD is assumed to be near the tissue T2 (65–100ms at 3 T), but this was never experimentally tested. In this study, we use a hypercapnia paradigm with SE-EPI at different TEs to identify the TE that maximizes BOLD detection at 3 T. Based on the normalized percent change in BOLD signal (∆BOLD%/mmHg), BOLD contrast-to-noise ratio (CNR/mmHg) and temporal signal-to-noise ratio (tSNR), we concluded that the optimal SE-EPI TE may be much shorter than the tissue T2, and the optimal TE at 3 T is near 50ms.

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