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Abstract #3729

Calibrated BOLD fMRI with an Optimized ASL-BOLD Dual-Acquisition Sequence

Maria A. Fernandez-Seara1, Zachary B. Rodgers2, Erin K. Englund2, Hee-Kwon Song2, John A. Detre3, Michael C. Langham2, and Felix W. Wehrli2

1Radiology, University of Navarra, Pamplona, Spain, 2Radiology, University of Pennsylvania, Philadelphia, PA, United States, 3Neurology, University of Pennsylvania, Philadelphia, PA, United States

Calibrated fMRI techniques estimate task-induced changes in the cerebral metabolic rate of oxygen (CMRO2) based on simultaneous measurements of cerebral blood flow (CBF) and blood-oxygen-level-dependent (BOLD) signal changes evoked by stimulation. To determine the calibration factor M (corresponding to the maximum possible BOLD signal increase), BOLD signal and CBF are measured in response to a gas breathing challenge (CO2, O2). Here we describe an ASL dual-acquisition sequence that combines a background-suppressed 3D readout with 2D multi-slice EPI. In five subjects we found an average gray matter M-value of 8.71±1.03 and fractional changes of CMRO2 of 12.5±5% in response to a bilateral motor task.

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