Abstract #3744

Mixed ICA and Clustering Method Introduced to Study the Life Span Changes in the Within-Network Functional Connectivity of the Default Mode Network

Isa Costantini¹, Ottavia Dipasquale^1,2, Laura Pelizzari^1,2, Maria Marcella Laganà², Francesca Baglio², and Giuseppe Baselli¹

¹Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy, ²IRCCS, Don Gnocchi Foundation, Milan, Italy

This study combines the independent component analysis and a local clustering method in order to study the within-network functional connectivity of the default mode network (DMN). Our results strongly support the hypothesis that the long-range FC between anterior and posterior DMN increases from the childhood to the young adulthood and slowly decreases with aging. This joint approach allowed us to obtain more detailed information about within-network FC changes among the DMN sub-regions.

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