Abstract #3748

The long-term reproducibility of stimulation and resting state fMRI in the mouse

Yi-Ching Lynn Ho^1,2, Fiftarina Puspitasari¹, and Kai-Hsiang Chuang¹

¹Singapore Bioimaging Consortium, Agency for Science, Technology & Research (A*STAR), Singapore, Singapore, ²Interdisciplinary Institute of Neuroscience & Technology (ZIINT), Zhejiang University, Hangzhou, China, People's Republic of

There is a need to evaluate the long-term reproducibility of stimulation and resting state fMRI in the mouse, given the technical challenges of mouse fMRI. We compared 2 sessions of scans done between 3-9 weeks apart on 7 C57BL/6 mice. The intraclass correlation (ICC) indicated significant absolute agreement for forepaw stimulation fMRI results. Interhemispheric functional connectivity scores for a large subcortical area like the CPu were also found to be reproducible, but in a small cortical area like the S1FL, reproducibility did not reach significance. Possible reasons include data coregistration mismatches due to distortion and susceptibility artifacts.

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