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Abstract #3757

Increased functional connectivity associates with the improved emotion regulation after 8-week mindfulness-based stress reduction (MBSR) training using resting-state fMRI analysis

Yao-Chia Shih1,2, Chang-Le Chen2,3, Shih-Chin Fang4, Tzung-Kuen Wen5, Da-Lun Tang6, Si-Chen Lee7, and Wen-Yih Issac Tseng2,3,8

1Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, 2Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, 3Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan, 4Department of Neurology, Cardinal Tien Hospital Yonghe Branch, New Taipei City, Taiwan, 5Department of Buddhist Studies, Dharma Drum Institute of Liberal Arts, New Taipei City, Taiwan, 6Department of Mass Communication, Tamkang University, Taipei, Taiwan, 7Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan, 8Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

Mindfulness-based stress reduction (MBSR) is modified from Buddhist traditions and aims to improve self-regulation. In this study, we employed the resting-state functional MRI to investigate changes of functional connectivity (FC) before and after MBSR practice, and before and after 8-week MBSR training. We hypothesized that changes in FC may reflect improvements of self-regulation after MBSR training. We found MBSR strengthened FC couplings of right subgenual anterior cingulate cortex and lateral middle orbitofrontal cortex with posterior cingulate cortex in the beginners after 8-week MBSR training. Our findings reveal an underlying neural mechanism of positive effects of MBSR practice on emotional regulation.

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