Abstract #3759

Long-term and acute cannabis effects on brain networks

Isabelle Berger^1,2,3, Philippe Maeder¹, Jean-Marie Annoni⁴, Haithem Chtioui⁵, Christian Giroud⁶, Bernard Favrat⁷, Kim Dao⁵, Marie Fabritius⁶, Jean-Frédéric Mall⁸, Giovanni Battistella^1,9, Reto Meuli¹, and Eleonora Fornari^1,2

¹Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV), and University of Lausanne, Lausanne, Switzerland, ²CIBM (Centre d'Imagerie Biomédicale), Centre Hospitalier Universitaire Vaudois (CHUV) unit, Lausanne, Switzerland, ³Department of Neurology, Besancon University Hospital, Besançon, France, ⁴Neurology Units, Department of Medicine, University of Fribourg, Fribourg, Switzerland, ⁵Department of Clinical Pharmacology and Toxicology, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland, ⁶CURML (University Center of Legal Medicine), UTCF (Forensic Toxicology and Chemistry Unit), Lausanne, Switzerland, ⁷CURML (University Center of Legal Medicine), UMPT (Unit of Psychology and Traffic Medicine), Lausanne, Switzerland, ⁸Department of Psychiatry, SUPAA (Service Universitaire de Psychiatrie de l'Age Avancé), CHUV, Lausanne, Switzerland, ⁹Department of Neurology, Icahn School of Médicine at Mount Sinai, New York, NY, United States

The purpose of our study was to reveal the changes in functional networks due to chronic and acute cannabis use, and to highlight the anterior insula specific involvement. We explored changes in functional connectivity by means of ICA and seed-based methods. Long-term cannabis use leads to an attenuation of the engagement of the Salience Network regions. The further decrease of activity after acute consumption can reflect the decrease of subject awareness in their performances, or a modulation of networks interplay. Modifications revealed by seed-based connectivity analysis support and clarify the insular role in cannabis addiction.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.