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Abstract #3761

Staging Alzheimer’s Disease Risk by Sequencing Brain Function and Structure, Cerebrospinal Fluid, and Cognition Biomarkers

Guangyu Chen1, Hao Shu1, Gang Chen1, Barney Douglas Ward1, Piero G Antuono2, and Shi-Jiang Li1

1biophysics, medical college of wisconsin, milwaukee, WI, United States, 2Neurology, medical college of wisconsin, milwaukee, WI, United States

A robust temporal ordering sequence of biomarkers for staging the Alzheimer’s disease (AD) progression risk is revealed by integrating brain function and structure, cerebrospinal fluid (CSF), and cognition biomarkers into an event-based model. In this study, we found that functional abnormality in the hippocampus and posterior cingulate cortex networks is the earliest event in the preclinical phase of AD, even antedating the detectable CSF Aβ and p-tau abnormalities; this sheds light on the link between preclinical AD status and its symptomatic onset for accurately identifying progressive AD trajectories along the disease course, given the condition that disease onset is insidious.

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