Abstract #3825

Alzheimer’s Disease is Associated with Hypo-Brain Entropy

Zhengjun Li¹ and Ze Wang^1,2

¹Psychiatry, University of Pennsylvania, Philadelphia, PA, United States, ²Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, China, People's Republic of

Brain entropy (BEN) mapping provides a way to characterize temporal brain dynamics, and thus the health of regional brain functionality. In this study, we aimed to examine its sensitivity for differentiating Alzheimer’s disease (AD) from healthy controls, as well as its relationship to AD severity. We found reduced BEN in the limbic and prefrontal area in AD compared to controls, and a negative correlation between BEN and AD severity in a widespread area of neural cortex. These results suggest BEN as a potential biomarker for AD.

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