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Abstract #3831

Modeling Resting Cerebral Perfusion from BOLD Signal Dynamics During Hyperoxia

M. Ethan MacDonald1, Avery J.L. Berman1,2, Erin L. Mazerolle1, Rebecca J. Williams1, and G. Bruce Pike1

1Departments of Radiology & Clinical Neurosciences, University of Calgary, Hotchkiss Brain Institute, Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, AB, Canada, 2Montreal Neurological Institute, Montreal, QC, Canada

In this work we demonstrate the use of BOLD-fMRI during hyperoxia to obtain perfusion parameters, including CBF, CBV, and MTT. During BOLD imaging, subjects breathing from a respiratory circuit inhaled air whose oxygen content was increased from 21% to 70%. The exhaled oxygen concentration was processed to obtain an arterial input function, and the concentration of bound oxygen in the venous blood was determined by modeling the BOLD time series. Through deconvolution modeling we were able to obtain measurements of CBF, venous CBV, and MTT within expected ranges.

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