Abstract #3836

Motion insensitive quantification of liver proton density fat-fraction using a single-shot 2D technique

Jeannine A. Ruby¹, Diego Hernando¹, Camilo A. Campo¹, Ann Shimakawa², Karl K. Vigen¹, James H. Holmes³, Kang Wang³, and Scott B. Reeder^1,4,5,6,7

¹Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²Global MR Applications and Workflow, GE Healthcare, Menlo Park, CA, United States, ³Global MR Applications and Workflow, GE Healthcare, Madison, WI, United States, ⁴Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁵Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ⁶Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁷Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

In this study, we developed and validated a “single-shot” sequential 2D-chemical shift-encoded MRI (CSE-MRI) technique for motion-insensitive quantification of liver proton density fat fraction (PDFF). A phantom of 11 vials with varying PDFF demonstrated equivalent PDFF between 2D- and 3D-CSE-MRI. Fifteen subjects underwent five different CSE-MRI acquisitions: 3D-single-breathhold (BH), slice-interleaved 2D-single-BH and free-breathing (FB), and sequential 2D-single-BH and FB. PDFF was measured and averaged across all nine Couinaud liver segments. Good agreement was observed in PDFF between all 2D-CSE-MRI acquisitions and 3D-CSE-MRI. Qualitative motion artifact evaluation demonstrated significantly superior scores for free-breathing “single-shot” sequential 2D-CSE-MRI compared to free-breathing slice-interleaved 2D-CSE-MRI.

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